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Vasileios Arzoglou

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Mr Arzoglou is a Consultant Neurosurgeon with a special interest in minimal invasive spinal surgery. His current post is as a NHS consultant neurosurgeon at Hull Royal Infirmary.His research interests include stem cells migration, and computational biomechanics. He has published in 2016 the first prospective study in Europe for a minimal invasive spinal fusion technique and is currently working on his PhD in the field of stem cell migration in malignant gliomas

 

James Fitzgerald

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James Fitzgerald is working on implanted electronic devices that interface directly with parts of the nervous system. At present his main research focus is on the development of a novel type of interface capable of recording signals from motor axons in severed peripheral nerves after amputation, with the aim of using these signals to control sophisticated prosthetic limbs. This requires advances in several areas including polymer microfabrication techniques, implantable electrophysiological recording systems, microsurgical implantation methods and the development of multichannel signal processing and pattern recognition algorithms.  A further problem is that, like virtually all surgical implants, interfaces evoke a foreign body response that leads to the deposition of scar tissue on their surfaces, which leads to gradual electrical failure of the device. A major strand of his work at present concerns the development of techniques for long term scar suppression.

He is also one of the 3 academic consultants in Oxford Functional Neurosurgery, which has one of the UK's largest clinical practices in deep brain stimulation, spinal cord and dorsal root ganglion stimulation and peripheral nerve stimulation for the treatment of movement disorders and neuropathic pain. Alongside and closely intertwined with this clinical work he is involved in a research programme investigating the mechanisms by which neuromodulation treatments work and how they can be improved and their use expanded to new indications.

 

Kanna Gnanalingham

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After studying Medicine in Manchester, Mr Gnanalingham completed his Neurosurgical training in London. He was appointed as a Consultant at the Greater Manchester Neuroscience Centre at Salford Royal Foundation Trust (SRFT) in 2005.

His sub-speciality interests include pituitary, anterior skull base and complex spine surgery, utilising minimally invasive techniques. He is the lead consultant for Pituitary surgery in Manchester and introduced the endoscopic approach to the region. SRFT is a national and international Visitation centre for Minimally Invasive Surgery, with regular visits from surgeons wishing to learn such ‘key hole’ surgical techniques.

He has a strong interest in clinical and basic science research in Neuroscience, qualified to a doctorate level, with over 80 publications and international presentations.

 

Ahmed Ibrahim

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Ahmed  Ibrahim graduated from St Bartholomew's and The Royal London Hospital and completed neurosurgical training at the North Thames London deanery.  Mr Ibrahim then went on to complete a fellowship in spinal surgery in Toronto, Canada under Professor Fehlings. Mr Ibrahim was awarded a PhD in axonal regeneration using stem cells from UCL.  He is currently a consultant neurosurgeon at Queens hospital and also continues his research activities in clinical and basic science research. 

David Jellinek

The Sheffield neurosurgery unit has two fields of research interest extending back over the tenure of David JELLINEK the CNS oncology lead. One laboratory based, the second clinical imaging. We have published basic science research on telomere biology and survival in GBM. We have an active basic science research programme in collaboration with Dr S Collis – Reader in molecular oncology University of Sheffield. This research is specifically interested in targeting dysregulated DNA repair pathways in glioma – specifically the Fanconi pathway. We have an active advanced imaging collaboration with the University of Sheffield – investigating clinical application advanced MRI imaging techniques for glioma.

 

Professor Marios Papadopoulos

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Marios C. Papadopoulos is the Professor of Neurosurgery at St. George’s, University of London. His research interests are aquaporin water channels (Nat Rev Neurosci 2013;14:265-77) and neuro-monitoring after spinal cord injury (Crit Care Med 2014;42:646-55). His clinical interests are complex spinal surgery and vascular neurosurgery. 

 

Thomas Santarius

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His clinical practice focuses on surgical treatment of brain tumours in children and adults, including those ventricular and periventricular tumours, sellar, parasellar and pineal region, cerebellum and brainstem. He has expertise in glioma surgery utilising intraoperative electrophysiological mapping and monitoring in awake and anaesthetised patients.

Teaching. He has co-founded Cambridge Lectures in Neurosurgical Anatomy. This course uses 3D images and videos of cadaveric dissections and as well as neurosurgical operations to promote perfection of surgical techniques through in-depth understanding of surgical anatomy.

His research focuses on fundamental biology of cancer and molecular genetics of brain tumours. He has described aspects of genomic amplifications at DNA sequence level, classified genomic amplifications in human cancer, described a novel human amplified cancer gene GLO1 and contributed to recent discovery of novel meningioma genes. Currently he is focussing on understanding the natural history and uncovering of the genetic makeup of anaplastic meningiomas and other rare brain tumours. As a part of his clinical interest in low-grade gliomas, he is striving to improve surgical techniques and understanding of language and executive brain functions.

 

Stuart Smith

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Stuart Smith currently works as Clinical Associate Professor of Neurosurgery at Nottingham University Hospitals. His research interests include both translational laboratory and clinical neuro-oncological work. He leads projects focusing mainly on high grade glioma, with his PhD studying angiogenesis in paediatric glioblastoma. He continues to work on paediatric glioblastoma, particularly microRNA control of the hypoxic response. He also runs projects studying adult glioblastoma, with a particular interest in intra-tumour heterogeneity at genetic and protein levels. Neurosurgical drug delivery is another key translational research programme within his group, developing a PLGA/PEG based biodegradable paste for delivery of multiple chemotherapeutics to residual glioblastoma. He is also local PI for clinical trials including RESCUE-ASDH and DEX-CSDH and lead several clinical neuro-oncological studies. His laboratory group includes research assistants, PhD and MSc students.

 

Mario Teo

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Mario Teo is a Consultant Neurosurgeon and Honorary Senior Clinical Lecturer at Bristol Institute of Clinical Neuroscience, North Bristol University Hospital, having completed a Cerebrovascular and Skull Base fellowship at Stanford University, California, USA. He has a special interest in minimally invasive neurosurgery (cranial and spine), management of skull base tumours and vascular pathologies including endoscopic endonasal approaches and cerebral revascularizations.

 

His research focus includes moyamoya disease, cerebral aneurysm, arteriovenous malformation, cavernoma, schwannoma, meningioma, skull base tumours and neurocutaneous disorders. He authored numerous peer-reviewed publications, editorials, book chapters, and is also an advocate of collaborative clinical and scientific research, at local, national and international level.

 

Professor Colin Watts

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Colin Watts’ research group aims to improve the treatment and survival of patients with Glioblastoma (GB) by understanding the molecular genetic heterogeneity of individual tumours and using that data to develop a novel molecular stratification of GB suitable for application in clinical trial design.

He qualified from the University of Newcastle upon Tyne and trained in neurosurgery in Cambridge and London where he completed his specialist training in 2004. His research training was supported by the MRC first as a Clinical Fellow, gaining his doctorate from the University of Cambridge in 1999, and subsequently as a Clinician Scientist. In 2010 he was awarded a HEFCE Clinical Senior Lecturer position at the University of Cambridge.

As a practicing neurosurgeon he has established a dedicated neurosurgical-oncology research clinic, which is closely integrated with his lab. His group has established protocols for the efficient derivation of tumour-initiating stem-like cells from fresh GBM samples and utilized them to develop patient-specific xenogeneic models. He has adapted fluorescent surgery to develop Fluorescence-Guided Multiple Sampling (FGMS), which allows spatially discrete tissue samples to be taken from individual patients. This is providing novel insights into the impact of surgical sampling bias on our understanding of the complex genomic landscape of GBM, its clonal architecture and phylogeny at the level of the individual patient.

His clinical research seeks to couple fluorescence-guided cytoreduction with locally delivered therapies. He is chief investigator in the GALA-5 trial, which aims to identify clinical benefit from combining fluorescence with intra-operative chemotherapy.

His clinical practice specialises in surgical neurooncology, with a particular interest in intrinsic gliomas and cerebral metastases.


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Last Updated: 22 July 2019