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Kristian Aquilina

Kristian Aquilina is a paediatric neurosurgeon at Great Ormond Street Hospital. His research interests are hydrocephalus, paediatric neuro-oncology and spasticity, particularly selective dorsal rhizotomy.

 

Professor Keyoumars Ashkan

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Keyoumars Ashkan is the Professor of Neurosurgery at King's College Hospital, London. His main research interests are in functional neurosurgery and neuro-oncology, including the effect of deep brain stimulation on motor and non-motor aspects of Parkinson's disease, optimisation of surgical targeting for movement disorders, paediatric deep brain stimulation, neuromodulation for psychiatric disorders, development of novel therapies for movement disorders and stroke, new treatments for brain tumours including immunotherapy, genetics and molecular pathology of brain tumours and patient reported outcome measures. He has over 100 peer reviewed papers cited in PubMed in these areas. He is the clinical lead for neuro-oncology and functional neurosurgery at King's. He is the Chair of King's Neuroscience clinical trials unit and the deputy chair of King's neuroscience research advisory group.

 

Andrew Brodbelt

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Consultant Neurosurgeon and divisional clinical director at the Walton Centre NHS foundation trust. Main research interests are in Syringomyelia/Chiari, CSF dynamics, and Neurooncology.  His PhD entitled 'Investigations into post traumatic syringomyelia' led to an interest in the underlying aetiology of the condition, the biomechanics, and the associated CSF dynamics.  Appointed as a consultant neurosurgeon and lead for neurosurgical oncology in 2005 has moved his interest more firmly into neurooncology.  Specific current interests include population based statistics for tumour types, the effect of volume on surgical outcomes, and long term survivors with glioblastoma. 

 

Paul Byrne

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Paul Byrne was appointed as a Consultant  in Nottingham in 1995. He is the lead Clinician East Midlands Rehion for Neuro-Oncology. He has taken part in national and iinternational trials involving blood-brain barrier drugs, gliadel and gene therapy.

 

Giles Critchley

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Giles Critchley is a consultant neurosurgeon at Brighton and Sussex University Hospitals NHS trust and Honorary Clinical Senior Lecturer at  Brighton and Sussex Medical School. His MD was in cerebral ischaemia following subarachnoid haemorrhage. Research interests include management of patients with high grade gliomas, outcome following spinal surgery and cerebral blood flow in the microcirculation. Local research collaborations with CISC, SHORE-C and School of Biological Sciences at the University of Sussex.

 

Professor Charles Davis

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Charles Davis has been a consultant neurosurgeon in Preston for more than 20 years.  His special interests are in relation to spinal problems and also brain tumours. He is currently Vice-President and President of the British Neuro-oncology Society which is a society for patients with brain tumours and includes members of the public, patients, scientists as well as doctors.  In 1989 we introduced the first commercially available image guided surgical service in Europe and this continues to develop with research collaboration at the University of Central Lancashire and other local universities under the heading of Brain Tumour North West.

 

Andreas Dementriades

Andreas Dementriades is a consultant neurosurgeon and honorary senior lecturer in Edinburgh. His areas of interest include spinal disorders (outcome measures for Cervical Spondylotic Myelopathy; C2 fractures; Oncology (primary/metastatic/intradural); all aspects of degenerative/trauma/oncology/infection, trigeminal neuralgia , Neuro-oncology: outcome measures of awake vs IOM techniques, Neurotrauma and training.

 

Tom Flannery

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Tom Flannery is a consultant neurosurgeon with a specialty interest in neuro-oncology and stereotactic radiosurgery based in Belfast and with an honorary contract at Leeds Gamma Knife Centre where he treats NI patients. He is the Clinical Lead for the regional neuro-oncology MDT and also involved in undergraduate teaching. His academic interests include biological mechanisms underpinning glioma invasion and radiation resistance and he is a member of the Brain Tumour Research Focus group based in the Centre for Cancer Research & Cell Biology in Queen’s University Belfast.

 

Mohsen Javadpour

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Mohsen Javadpour is a consultant neurosurgeon in Dublin with a particular academic interest in subarachnoid haemorrhage, brain aneurysms and vascular malformations, pituitary tumours and craniopharyngiomas

 

David Jellinek

The Sheffield neurosurgery unit has two fields of research interest extending back over the tenure of David JELLINEK the CNS oncology lead. One laboratory based, the second clinical imaging. We have published basic science research on telomere biology and survival in GBM. We have an active basic science research programme in collaboration with Dr S Collis – Reader in molecular oncology University of Sheffield. This research is specifically interested in targeting dysregulated DNA repair pathways in glioma – specifically the Fanconi pathway. We have an active advanced imaging collaboration with the University of Sheffield – investigating clinical application advanced MRI imaging techniques for glioma.


Michael Jenkinson

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Michael Jenkinson is a senior lecturer and honorary consultant neurosurgeon at the University of Liverpool and Walton Centre NHS Foundation Trust.  He sub-specialises in neurosurgical oncology including awake craniotomy, intraventricular / pineal tumours and stereotactic radiosurgery.

His research interests include imaging and biology of gliomas, cerebral metastases and meningoma, and clinical studies on quality of life in brain tumours.  The Walton Centre has a fully resourced tumour biobank which facilitates research with collaborative partners in the UK and overseas.  He is the recipient of grants for basic science and clinical research from the MRC and NIHR.  These include being chief investigator for the international, multi-centre ROAM trial (Radiation versus Observation following surgical resection of Atypical Meningioma) and co-chief investigator on the multi-centre national BASICS trial (The British Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts randomized controlled trial).

Please contact michael.jenkinson@liv.ac.uk if you are interested in developing a research collaboration or would like to undertake a clinical or laboratory research training post in Liverpool.

 

John Leach

John Leach is a Consultant Neurosurgeon in  Manchester. His sub-specialty interests are Spine and Neuro-oncology. He was the Clinical Lead 2012-15 and the sub-specialty Lead for Spine. He completed his neurosurgical training in Oxford and Melbourne. His research interests are Saccadic eye movements,  Gliomas, Lumbar disc disease, Intramedullary spine tumours

 

Edward McKintosh

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Edward McKintosh is a Consultant Neurosurgeon at the Royal London Hospital with a subspecialist interest in neuro-oncology and neuroendoscopy and a research interest in neuro-oncology.

 

Nitin Mukerji

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Nitin Mukerji is a Consultant Neurosurgeon at James Cook University Hospital, Middlesbrough. After training in the Northern Deanery, he completed a Cerebrovascular and Skull base fellowship at Stanford University, was a visiting fellow at UCSF and obtained a masters in applied statistics.  Prior to joining Neurosurgery, he had completed a residency in Ophthalmology with a special interest in corneal disease. His research interests include epidemiology of cerebrovascular conditions, morphological basis of aneurysm rupture, non-invasive ICP monitoring and cerebral revascularization. He is also involved in research in the field of neuro-oncology and CSF dynamics.

 

Stephen Price

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My research uses both MRI and PET imaging methods to study heterogeneity in brain tumours. I am particularly interested in both the invasive margin and the response of tumours to therapy. My work with diffusion tensor imaging has produced a method of identifying the invasive margin of gliomas. This has been confirmed histologically and is able to identify patterns of tumour progression and the time to progression.  I am the chief investigator on the CRUK Funded PRaM-GBM study that will validate these imaging biomarkers in a multicentre study. Using this method has allowed us to use other imaging modalities to study the invasive microenvironment of gliomas and we plan to use this as a method of assessing response to therapy/disease progression. My current work has tried to better understand invasive phenotypes and use these imaging methods to redefine the target for surgical and radiotherapy. I also have a developing interest in quality of life and outcome assessment in neuro-oncology.

 

Thomas Santarius

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His clinical practice focuses on surgical treatment of brain tumours in children and adults, including those ventricular and periventricular tumours, sellar, parasellar and pineal region, cerebellum and brainstem. He has expertise in glioma surgery utilising intraoperative electrophysiological mapping and monitoring in awake and anaesthetised patients.

Teaching. He has co-founded Cambridge Lectures in Neurosurgical Anatomy. This course uses 3D images and videos of cadaveric dissections and as well as neurosurgical operations to promote perfection of surgical techniques through in-depth understanding of surgical anatomy.

His research focuses on fundamental biology of cancer and molecular genetics of brain tumours. He has described aspects of genomic amplifications at DNA sequence level, classified genomic amplifications in human cancer, described a novel human amplified cancer gene GLO1 and contributed to recent discovery of novel meningioma genes. Currently he is focussing on understanding the natural history and uncovering of the genetic makeup of anaplastic meningiomas and other rare brain tumours. As a part of his clinical interest in low-grade gliomas, he is striving to improve surgical techniques and understanding of language and executive brain functions.

Stuart Smith

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Stuart Smith currently works as Clinical Associate Professor of Neurosurgery at Nottingham University Hospitals. His research interests include both translational laboratory and clinical neuro-oncological work. He leads projects focusing mainly on high grade glioma, with his PhD studying angiogenesis in paediatric glioblastoma. He continues to work on paediatric glioblastoma, particularly microRNA control of the hypoxic response. He also runs projects studying adult glioblastoma, with a particular interest in intra-tumour heterogeneity at genetic and protein levels. Neurosurgical drug delivery is another key translational research programme within his group, developing a PLGA/PEG based biodegradable paste for delivery of multiple chemotherapeutics to residual glioblastoma. He is also local PI for clinical trials including RESCUE-ASDH and DEX-CSDH and leads several clinical neuro-oncological studies. His laboratory group includes research assistants, PhD and MSc students.

 

Simon Thomson

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Mr Thomson's academic interests are in two areas: post-graduate neurosurgical education and clinical high grade tumour research.  Mr Thomson is the Neurosurgical lead for an international online elearning programme www.ebrainjnc.com, has developed an annual formative in-training exam in Neurosurgery, sits on the Specialist Advisory Committee for training in Neurosurgery and is joint editor of the Oxford Textbook of Neurosurgery.  Mr Thomson is either chief or principle investigator on a number of surgical trials including for example GALA5, photodynamic therapy for pituitary adenomas and a proposed trial on cervical foraminotomy. His main area of interest is in clinical trials related to the surgical aspects of high grade glioma and metastatic tumours.

 

Professor Colin Watts

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Colin Watts’ research group aims to improve the treatment and survival of patients with Glioblastoma (GB) by understanding the molecular genetic heterogeneity of individual tumours and using that data to develop a novel molecular stratification of GB suitable for application in clinical trial design.

He qualified from the University of Newcastle upon Tyne and trained in neurosurgery in Cambridge and London where he completed his specialist training in 2004. His research training was supported by the MRC first as a Clinical Fellow, gaining his doctorate from the University of Cambridge in 1999, and subsequently as a Clinician Scientist. In 2010 he was awarded a HEFCE Clinical Senior Lecturer position at the University of Cambridge. He moved to Birmingham in 2018 where he is currently the Chair of Neurosurgery.

As a practicing neurosurgeon he has established a dedicated neurosurgical-oncology research clinic, which is closely integrated with his lab. His group has established protocols for the efficient derivation of tumour-initiating stem-like cells from fresh GBM samples and utilized them to develop patient-specific xenogeneic models. He has adapted fluorescent surgery to develop Fluorescence-Guided Multiple Sampling (FGMS), which allows spatially discrete tissue samples to be taken from individual patients. This is providing novel insights into the impact of surgical sampling bias on our understanding of the complex genomic landscape of GBM, its clonal architecture and phylogeny at the level of the individual patient.

His clinical research seeks to couple fluorescence-guided cytoreduction with locally delivered therapies. He is chief investigator in the GALA-5 trial, which aims to identify clinical benefit from combining fluorescence with intra-operative chemotherapy.

His clinical practice specialises in surgical neurooncology, with a particular interest in intrinsic gliomas and cerebral metastases.


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Last Updated: 26 March 2019